Your browser does not support JavaScript!
Recovery to Practice Bridging People, Knowledge, Tools, and Experience

Search by Keyword

Explore Profession
RTP Quick Links

Antidepressant use and risk of adverse outcomes in older people: population based cohort study

Julia Hippisley-Cox, Garry Barton, Antony Arthur, Paula Dhiman, Carol Coupland


Objectives: To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to examine risks by class of antidepressant, duration of use, and dose.


↵McDougall FA, Matthews FE, Kvaal K, Dewey ME, Brayne C. Prevalence and symptomatology of depression in older people living in institutions in England and Wales. Age Ageing2007;36:562-8.FREE Full Text ↵Beekman AT, Copeland JR, Prince MJ. Review of community prevalence of depression in later life. Br J Psychiatry1999;174:307-11.FREE Full Text ↵The NHS Information Centre Prescribing Support Unit. Prescriptions dispensed in the community, statistics for 1999 to 2009: England. The Health and Social Care Information Centre, 2010. ↵The NHS Information Centre Prescribing Support Unit. Prescription cost analysis: England 2009. The Health and Social Care Information Centre, 2010. ↵The NHS Information Centre Prescribing Support Unit. Prescription cost analysis: England 2004. The Health and Social Care Information Centre, 2005. ↵Mottram P, Wilson K, Strobl J. Antidepressants for depressed elderly. Cochrane Database Syst Rev 2006;1:CD003491.Medline ↵National Institute for Health and Clinical Excellence. Depression: the treatment and management of depression in adults (update). NICE, 2009. (National Clinical Practice Guideline 90.) ↵Cadieux RJ. Antidepressant drug interactions in the elderly: understanding the P-450 system is half the battle in reducing risks. Postgrad Med1999;106:231-2.Medline ↵Giron MS, Fastbom J, Winblad B. Clinical trials of potential antidepressants: to what extent are the elderly represented? A review. Int J Geriatr Psychiatry2005;20:201-17.CrossRefMedlineWeb of Science ↵Pollock BG. Adverse reactions of antidepressants in elderly patients. J Clin Psychiatry1999;60(suppl 20):4-8. ↵Parikh C. Antidepressants in the elderly: challenges for study design and their interpretation. Br J Clin Pharmacol2000;49:539-47.MedlineWeb of Science ↵Reid S, Barbui C. Long term treatment of depression with selective serotonin reuptake inhibitors and newer antidepressants. BMJ2010;340:c1468.FREE Full Text ↵Coupland C, Dhiman P, Barton G, Morriss R, Arthur A, Sach T, et al. A study of the safety and harms of antidepressant drugs for older people: a cohort study analysis using a large primary care database. Health Technol Assess 2011 (forthcoming). ↵Hippisley-Cox J, Vinogradova Y, Coupland C, Pringle M. Comparison of key practice characteristics between general practices in England and Wales and general practices in the QRESEARCH database: report to the Health and Social Care Information Centre. University of Nottingham, 2005. ↵Hippisley-Cox J, Pringle M, Hammersley V, Crown N, Wynn A, Meal A, et al. Antidepressants as risk factor for ischaemic heart disease: case-control study in primary care. BMJ2001;323:666-9.FREE Full Text ↵Martinez C, Rietbrock S, Wise L, Ashby D, Chick J, Moseley J, et al. Antidepressant treatment and the risk of fatal and non-fatal self harm in first episode depression: nested case-control study. BMJ2005;330:389.FREE Full Text ↵British Medical Association, Royal Pharmaceutical Society of Great Britain. British national formulary. BMA, RPS, 2007. (No 54.) ↵Townsend P, Phillimore P, Beattie A. Health and deprivation: inequality and the north. Croom Helm, 1988. ↵Altman DG, Andersen PK. Calculating the number needed to treat for trials where the outcome is time to an event. BMJ1999;319:1492-95.FREE Full Text ↵Furukawa TA, McGuire H, Barbui C. Low dosage tricyclic antidepressants for depression. Cochrane Database Syst Rev 2003;3:CD003197.Medline ↵Cassano P, Fava M. Depression and public health: an overview. J Psychosom Res2002;53:849-57.CrossRefMedlineWeb of Science ↵Nicholson A, Kuper H, Hemingway H. Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies. Eur Heart J2006;27:2763-74.FREE Full Text ↵Hippisley-Cox J, Fielding K, Pringle M. Depression as a risk factor for ischaemic heart disease in men: population based case-control study. BMJ1998;316:1714-9.FREE Full Text ↵Hubbard R, Farrington P, Smith C, Smeeth L, Tattersfield A. Exposure to tricyclic and selective serotonin reuptake inhibitor antidepressants and the risk of hip fracture. Am J Epidemiol2003;158:77-84.FREE Full Text ↵Whitaker HJ, Farrington CP, Spiessens B, Musonda P. Tutorial in biostatistics: the self-controlled case series method. Stat Med2006;25:1768-97.CrossRefMedlineWeb of Science ↵Herrett E, Thomas SL, Schoonen WM, Smeeth L, Hall AJ. Validation and validity of diagnoses in the General Practice Research Database: a systematic review. Br J Clin Pharmacol 2010;69:4-14.CrossRefMedlineWeb of Science ↵Khan NF, Harrison SE, Rose PW. Validity of diagnostic coding within the General Practice Research Database: a systematic review. Br J Gen Pract2010;60:e128-36.CrossRefMedline ↵Stone M, Laughren T, Jones ML, Levenson M, Holland PC, Hughes A, et al. Risk of suicidality in clinical trials of antidepressants in adults: analysis of proprietary data submitted to US Food and Drug Administration. BMJ2009;339:b2880.FREE Full Text ↵Barbui C, Esposito E, Cipriani A. Selective serotonin reuptake inhibitors and risk of suicide: a systematic review of observational studies. CMAJ2009;180:291-7.FREE Full Text ↵Monster TBM, Johnsen SP, Olsen ML, McLaughlin JK, Sorensen HT. Antidepressants and risk of first-time hospitalization for myocardial infarction: a population-based case-control study. Am J Med 2004;117:732-7.CrossRefMedlineWeb of Science ↵Tata LJ, West J, Smith C, Farrington P, Card T, Smeeth L, et al. General population based study of the impact of tricyclic and selective serotonin reuptake inhibitor antidepressants on the risk of acute myocardial infarction. Heart2005;91:465-71.FREE Full Text ↵Cohen HW, Gibson G, Alderman MH. Excess risk of myocardial infarction in patients treated with antidepressant medications: association with use of tricyclic agents. Am J Med2000;108:2-8.MedlineWeb of Science ↵Blanchette CM, Simoni-Wastila L, Zuckerman IH, Stuart B. A secondary analysis of a duration response association between selective serotonin reuptake inhibitor use and the risk of acute myocardial infarction in the aging population. Ann Epidemiol 2008;18:316-21.CrossRefMedlineWeb of Science ↵Sauer WH, Berlin JA, Kimmel SE. Effect of antidepressants and their relative affinity for the serotonin transporter on the risk of myocardial infarction. Circulation2003;108:32-6.FREE Full Text ↵Schlienger RG, Fischer LM, Jick H, Meier CR. Current use of selective serotonin reuptake inhibitors and risk of acute myocardial infarction. Drug Saf2004;27:1157-65.CrossRefMedlineWeb of Science ↵Tiihonen J, Lonnqvist J, Wahlbeck K, Klaukka T, Tanskanen A, Haukka J. Antidepressants and the risk of suicide, attempted suicide, and overall mortality in a nationwide cohort. Arch Gen Psychiatry2006;63:1358-67.FREE Full Text ↵Smoller JW, Allison M, Cochrane BB, Curb JD, Perlis RH, Robinson JG, et al. Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women’s Health Initiative Study. Arch Intern Med2009;169:2128-39.FREE Full Text ↵Trifiro G, Dieleman J, Sen EF, Gambassi G, Sturkenboom M. Risk of ischemic stroke associated with antidepressant drug use in elderly persons. J Clin Psychopharmacol2010;30:252-8.CrossRefMedlineWeb of Science ↵Skop B, Brown T. Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors. Psychosomatics1996;37:12-6.Medline ↵Schlienger RG, Meier CR. Effect of selective serotonin reuptake inhibitors on platelet activation: can they prevent acute myocardial infarction? Am J Cardiovasc Drugs2003;3:149-62.CrossRefMedline ↵Darowski A, Chambers SACF, Chambers DJ. Antidepressants and falls in the elderly. Drug Aging2009;26:381-94.CrossRefMedlineWeb of Science ↵Kerse N, Flicker L, Pfaff JJ, Draper B, Lautenschlager NT, Sim M, et al. Falls, depression and antidepressants in later life: a large primary care appraisal. PLoS One2008;3:e2423.CrossRefMedline ↵Kallin K, Gustafson Y, Sandman P-O, Karlsson S. Drugs and falls in older people in geriatric care settings. Aging Clin Exp Res2004;16:270-6.MedlineWeb of Science ↵Arfken CL, Wilson JG, Aronson SM. Retrospective review of selective serotonin reuptake inhibitors and falling in older nursing home residents. Int Psychogeriatr2001;13:85-91.CrossRefMedlineWeb of Science ↵Ziere G, Dieleman JP, van der Cammen TJM, Hofman A, Pols HAP, Stricker BHC. Selective serotonin reuptake inhibiting antidepressants are associated with an increased risk of nonvertebral fractures. J Clin Psychopharmacol 2008;28:411-7.MedlineWeb of Science ↵Richards JB, Papaioannou A, Adachi JD, Joseph L, Whitson HE, Prior JC, et al. Effect of selective serotonin reuptake inhibitors on the risk of fracture. Arch Intern Med2007;167:188-94.FREE Full Text ↵Vestergaard P, Rejnmark L, Mosekilde L. Selective serotonin reuptake inhibitors and other antidepressants and risk of fracture. Calcif Tissue Int2008;82:92-101.CrossRefMedlineWeb of Science ↵Haney EM, Chan BK, Diem SJ, Ensrud KE, Cauley JA, Barrett-Connor E, et al. Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men. Arch Intern Med2007;167:1246-51.FREE Full Text ↵Diem SJ, Blackwell TL, Stone KL, Yaffe K, Cauley JA, Whooley MA, et al. Depressive symptoms and rates of bone loss at the hip in older women. J Am Geriatr Soc2007;55:824-31.CrossRefMedlineWeb of Science ↵De Abajo FJ, Rodriguez LAG, Montero D. Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study. BMJ1999;319:1106-9.FREE Full Text ↵De Abajo FJ, Garcia-Rodriguez LA. Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy: interaction with nonsteroidal anti-inflammatory drugs and effect of acid-suppressing agents. Arch Gen Psychiatry2008;65:795-803.FREE Full Text ↵Van Walraven C, Mamdani MM, Wells PS, Williams JI. Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study. BMJ2001;323:655-8.FREE Full Text ↵De Abajo FJ, Montero D, García Rodríguez LA, Madurga M. Antidepressants and risk of upper gastrointestinal bleeding. Basic Clin Pharmacol Toxicol2006;98:304-10.CrossRefMedlineWeb of Science ↵Opatrny L, Delaney JAC, Suissa S. Gastro-intestinal haemorrhage risks of selective serotonin receptor antagonist therapy: a new look. Br J Clin Pharmacol2008;66:76-81.CrossRefMedlineWeb of Science ↵Spigset O, Hedenmalm K. Hyponatremia in relation to treatment with antidepressants: a survey of reports in the World Health Organization database for spontaneous reporting of adverse drug reactions. Pharmacotherapy1997;17:348-52.MedlineWeb of Science ↵Movig KLL, Leufkens HGM, Lenderink AW, van den Akker VGA, Hodiamont PPG, Goldschmidt HMJ, et al. Association between antidepressant drug use and hyponatraemia: a case-control study. Br J Clin Pharmacol2002;53:363-9.CrossRefMedlineWeb of Science ↵Kirby D, Harrigan S, Ames D. Hyponatraemia in elderly psychiatric patients treated with selective serotonin reuptake inhibitors and venlafaxine: a retrospective controlled study in an inpatient unit. Int J Geriatr Psychiatry2002;17:231-7.CrossRefMedlineWeb of Science ↵Jacob S, Spinler SA. Hyponatremia associated with selective serotonin-reuptake inhibitors in older adults. Ann Pharmacother2006;40:1618-22.FREE Full Text ↵Kirby D, Ames D. Hyponatraemia and selective serotonin re-uptake inhibitors in elderly patients. Int J Geriat Psychiatry2001;16:484-93.CrossRefMedlineWeb of Science ↵Bingefors K, Isacson D, Knorring LV, Smedby B, Wicknertz K. Antidepressant-treated patients in ambulatory care—mortality during a nine-year period after first treatment. Br J Psychiatry1996;169:647-54.FREE Full Text ↵Ryan J, Carriere I, Ritchie K, Stewart R, Toulemonde G, Dartigues J-F, et al. Late-life depression and mortality: influence of gender and antidepressant use. Br J Psychiatry2008;192:12-8.FREE Full Text ↵Rosenstein DL, Nelson JC, Jacobs SC. Seizures associated with antidepressants: a review. J Clin Psychiatry1993;54:289-99.MedlineWeb of Science ↵Ray WA, Fought RL, Decker MD. Psychoactive drugs and the risk of injurious motor vehicle crashes in elderly drivers. Am J Epidemiol1992;136:873-83.FREE Full Text ↵Leveille S, Buchner D, Koepsell T, McCloskey L, Wolf M, Wagner E. Psychoactive medications and injurious motor vehicle collisions involving older drivers. Epidemiology1994;5:591-8.MedlineWeb of Science ↵Vassilev ZP, Chu AF, Ruck B, Adams EH, Marcus SM. Evaluation of adverse drug reactions reported to a poison control center between 2000 and 2007. Am J Health Syst Pharm2009;66:481-7.FREE Full Text

Go to 'Antidepressant use and risk of adverse outcomes in older people: population based cohort study'External Web Site Policy
Contributed on 12/14/2012

Type of Resource

Relevant Topics