This report provides prevalence estimates and 95% confidence intervals for persons aged 12 or older, 12 to 17, 18 to 25, and 26 or older; also for persons 12 to 20 for two alcohol measures. These are tables of State estimates for 25 measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Results are provided by State by age group.