This publication presents national estimates of drug-related visits to hospital emergency departments (EDs) for 2010, based on data from the Drug Abuse Warning Network (DAWN). Also presented are comparisons of 2010 estimates with those for 2004, 2008 and 2009. Chapter topics include overall drug misuse and abuse, illicit drugs, alcohol (drugs and alcohol taken together, underage drinking), nonmedical use of pharmaceuticals, drug-related suicide attempts, seeking detox services, adverse reactions to pharmaceuticals and accidental ingestion of drugs.