This report presents the total number of admissions to and discharges from substance use treatment services in 2021 by demographics, National Outcome Measures (NOMs), morbidity status, and the top six primary substances by geographic distribution. The NOMs presented in this report include stability in housing, employment status, criminal justice involvement, social support, retention in treatment, and abstinence. Data include records for treatment admissions and discharges that were received and processed through October 18, 2022.