This national report summarizes key findings from the 2016 National Survey on Drug Use and Health (NSDUH) for indicators of substance use and mental health among people aged 12 years old or older in the civilian, noninstitutionalized population of the United States. Estimates include tobacco use, alcohol use, illicit drug use, opioid use, substance use disorders, major depressive episode, any mental illness, serious mental illness, suicide, co-occurring disorders, and receipt of treatment or services.