Monitoring the distribution and impact of opioid overdose reversal medications such as naloxone is essential to optimizing overdose prevention strategies and improving public health outcomes. This Statistical Data Profile, the first to use performance data from two SAMHSA grant programs, examines the distribution of FDA-approved opioid overdose reversal medications, including naloxone/Narcan. The Data Profile also presents the training of first responders, community organization staff and other individuals to administer the reversal medications and provide other support services.