This report presents national- and state-level data from the Treatment Episode Data Set (TEDS) for admissions and discharges occurring in 2020, and trend data from 2010 to 2021. It summarizes demographic information and the characteristics and outcomes of treatment for alcohol and/or drug use among clients aged 12 years and older in facilities that report to individual state administrative data systems. Data include records for treatment admissions and discharges that were received and processed through November 22, 2021.