Centerstone REACH Florida (Reach-FL) will develop/implement targeted strategies for substance use disorder (SUD) treatment provision for 200 unduplicated adults (18+) with SUD and/or co-occurring substance use/mental disorders (COD) in the catchment area (Yr 1: 50; Yrs 2-3: 75, annually). Reach-FL will expand/enhance areas of focus to provide comprehensive, evidence-based services, including screening/assessment, outpatient/telehealth treatment, ECHO-based model of care, peer supports, care coordination, wraparound/recovery support services, etc. Reach-FL’s catchment area includes DeSoto, Manatee and Sarasota counties in Central Florida. Reach-FL’s focus population encompasses an anticipated 48,000 catchment area adults (18+) with SUD, including 22,700 with COD. Focus population demographics are expected to mirror those of the catchment area, with 48% male, 52% female, 90% White, 6% African American, 11% Hispanic, and 6% unemployed individuals; 22% are expected to lack health insurance. Reach-FL’s subpopulations include the 12% who are Veterans, 1% with OUD, 11% from racial/ethnic minorities, and/or 8% from rural areas. Of those in the focus population with COD, only 7% will receive both substance use and mental health services. In 2015, the catchment area region had the state’s highest number of opioid-caused deaths (710), and from 2012-2017, heroin related deaths increased by 855% (18 to 172). Reach-FL will deliver evidence-based SUD treatments/interventions according to NIDA’s Principles of Drug Addiction Treatment and SAMHSA’s Treatment Improvement Protocol (TIP) 42: Substance Abuse Treatment for Persons With Co-Occurring Disorders, integrating evidence-based techniques/therapies (e.g., Motivational Interviewing, Cognitive Behavioral Therapy, 12-Step Facilitation), plus relapse prevention, skills development, peer recovery supports, individual/family/group therapy, etc. Clients will be provided/referred to MAT as appropriate according to SAMHSA’s TIP 63: Medications for Opioid Use Disorder. Key Reach-FL strategies/interventions include community collaborations; assembly of Advisory Council; development of program policies/procedures; provision of teleECHO training/resources, enhancement/implementation of telehealth and related technologies; outreach/engagement; screenings/assessments; development of Individual Treatment Plans; provision of outpatient/telehealth SUD/COD treatment, medication delivery/management, care coordination, recovery coaching/peer recovery support services (e.g., housing/employment, benefits enrollment, transportation); monitoring/tracking participant health status; completion/dissemination of comprehensive evaluation; and implementation of a sustainability plan and marketing campaign. Reach-FL goals include: Increase access to SUD/COD treatment to address need among underserved adults; Develop infrastructure/capacity to expand, enhance, and sustain a comprehensive continuum of evidence-based treatment and recovery support services for adults experiencing SUD/COD; Improve clients’ health status and outcomes; and Develop/disseminate a replicable service model. Reach-FL will achieve the following measurable objectives: Conduct outreach/engagement to 1,000 individuals to recruit clients/promote buy-in; Provide training/workforce development (e.g., teleECHO) for 100 staff/community providers; Increase substance use abstinence by 60%; Reduce mental health symptomatology by 50%; Assist 100% in need with recovery support/resources (e.g., employment, housing support); Increased social connectedness by 70%; and Achieve 80% client retention. Reach-FL has secured commitments from partners dedicated to the project’s success, and will collaborate with community providers, law enforcement/courts, coalitions, social service agencies, key stakeholders, etc.