Strengthening the Capacity in Rural Maryland to Address Opioid Misuse University of Maryland Extension (UME) will strengthen the capacity of rural communities to recognize, understand, and respond to opioid issues in Maryland by a) delivering evidence-based training on opioid prevention and treatment, building upon UME programs and partnerships and b) providing current and scientific information, resources, and training in person and virtually on opioid misuse for individuals, families, practitioners, and communities. This proposed project will mobilize UME programs such as Agriculture, FCS, Environment and Natural Resources, and 4-H including extension educators, community partners, leaders, and volunteers, located in rural MD: Western Maryland (Garret, Allegany, Washington), Upper Eastern Shore (Harford, Cecil, Kent, Queen Anne’s), and Mid/low Eastern shore (Caroline, Dorchester, Talbot, Somerset, Worcester, and Wicomico counties). In collaboration with Center for Substance Abuse Research, School of Public Health, MayaTech, Maryland Rural Health Association, the program goals and activities for the next two years will include: Goal 1 Increase community capacity to reduce OUD and opiate-related overdose and deaths by delivering evidence based program (EBP) Mental Health First Aid (MHFA). a) MHFA instructors training will be provided for 120 educators (60 each year), and b) MHFA (8-hour) curriculum will be delivered to 500 community leaders and service providers (250 each year). Goal 2 Decrease youth substance use susceptibility by implementing Botvin Lifeskills (EBP) to strengthen youth social skills and behaviors and decrease substance use initiation. Training will be provided for a) 40 educators (20 each year), b) 650 middle school students (250 in year 1; 400 in year 2) and c) their parent/caregiver. Goal 3 Increase community capacity by providing TA/T. a) Establishing an advisory group on Rural Maryland Opioid Issues and creating a virtual network of Extension and community educators, partners, and local practitioners; b) Provide 6 virtual training on up-to-date resources and information for educators and practitioners (Y1: 150 Y2: 150 Total: 300 ) and 8 webinars for individuals, families, practitioners and communities (Y1: 200 Y2: 200 Total: 400 ) and in-person (Y1 240: Y2: 360 Total: 600); and c) Web-based content that supports virtual on-demand training for public, resources in rural Maryland, and SAMHSA’s State Targeted Response TA resources. The project will increase the number of trained community educators to address opioid misuse, strengthen the collaboration and coordination among educators and practitioners, and increase the information dissemination and relevant resources on opioid prevention and treatment for individuals, communities and practitioners.