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Strategic Prevention Framework for Prescription Drugs

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Short Title: SPF Rx
Modified Announcement Back to the Grants Dashboard

Revisions made to FOA Description, Key Personnel, Required Activities, and Eligibility

Notice of Funding Opportunity (NOFO)

NOFO Number: SP-21-001

Posted on Monday, March 01, 2021

Application Due Date: Friday, April 30, 2021

Catalog of Federal Domestic Assistance (CFDA) Number: 93.243

Intergovernmental Review (E.O. 12372):

Public Health System Impact Statement (PHSIS) / Single State Agency Coordination:


The Substance Abuse and Mental Health Services Administration (SAMHSA), Center for Substance Abuse Prevention (CSAP), is accepting applications for fiscal year (FY) 2021 Strategic Prevention Framework for Prescription Drugs (Short Title: SPF Rx) grant program. The SPF Rx grant program provides an opportunity for states, U.S. territories, (herein referred to as “states”), and Tribal entities that have completed a Strategic Prevention Framework Partnership For Success (SPF PFS) to target the priority issue of prescription drug misuse or another state-level strategic planning process around prescription drug misuse prevention. The program is designed to raise awareness about the dangers of sharing medications and work with pharmaceutical and medical communities on the risks of overprescribing to young adults. The SPF Rx program will also raise community awareness and bring prescription drug abuse prevention activities and education to schools, communities, parents, prescribers, and their patients. In addition, SAMHSA will track reductions in opioid overdoses and the incorporation of Prescription Drug Monitoring Program (PDMP) data into needs assessments and strategic plans as indicators of the program’s success.


Eligibility is limited to states, U.S. territories, and tribal entities that have completed a Strategic Prevention Framework Partnership For Success (SPF PFS) or a similar state-level strategic plan for the prevention of prescription drug misuse and have a state run PDMP.

Award Information

Funding Mechanism: Grant

Anticipated Total Available Funding: $10,000,000

Anticipated Number of Awards: 26

Anticipated Award Amount: Up to $384,000 per year

Length of Project: Up to 5 years

Cost Sharing/Match Required?: No

Proposed budgets cannot exceed $384,000 in total costs (direct and indirect) in any year of the proposed project. Annual continuation awards will depend on the availability of funds, grantee progress in meeting project goals and objectives, timely submission of required data and reports, and compliance with all terms and conditions of award.)

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