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Strategic Prevention Framework-Partnerships for Success

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Short Title: SPF-PFS
Initial Announcement Back to the Grants Dashboard

Notice of Funding Opportunity (NOFO)

NOFO Number: SP-22-004

Posted on Tuesday, April 12, 2022

Application Due Date: Monday, June 13, 2022

Catalog of Federal Domestic Assistance (CFDA) Number: 93.243

Intergovernmental Review (E.O. 12372): Applicants must comply with E.O. 12372 if their state(s) participates. Review process recommendations from the State Single Point of Contact (SPOC) are due no later than 60 days after application deadline.

Public Health System Impact Statement (PHSIS) / Single State Agency Coordination: Applicants must send the PHSIS to appropriate State and local health agencies by application deadline. Comments from Single State Agency are due no later than 60 days after application deadline.


The purpose of this grant program is to help reduce the onset and progression of substance misuse and its related problems by supporting the development and delivery of state and community substance misuse prevention and mental health promotion services. The SPF-PFS program is grounded in the Strategic Prevention Framework (SPF), a community engagement model grounded in public health principles, including being data-driven, and focused on providing evidence-based services to high-risk underserved communities. SPF-PFS grant recipients focus on strengthening state and community-level prevention capacity to identify and address local substance use prevention concerns, such as underage drinking, marijuana, tobacco, electronic cigarettes, opioids, and heroin. Using local, state, and national substance use public health data, recipients will identify prevention priorities in their communities, and develop and implement strategies to prevent the misuse of substances and promote mental health and well-being among youth and adults. Recipients will utilize a data-driven approach to identify underserved communities and at-risk sub-populations of focus.


Eligible applicants are domestic public and private nonprofit entities, which may include but is not limited to states, territories, jurisdictions, communities, community-based organizations, federally recognized Tribes and Tribal organizations, and Urban Indian Organizations.

Award Information

Funding Mechanism: Grant

Anticipated Total Available Funding: $8.8 million

Anticipated Number of Awards: 5 states; 7 communities

Anticipated Award Amount: Up to $375,000 per year for community, tribal, or territory applicants; Up to $1,250,000 for state applicants.

Length of Project: Up to 5 years

Cost Sharing/Match Required?: No

Proposed budgets cannot exceed $375,000 for communities, tribes, or territories, and $1,250,000 for states in total costs (direct and indirect) in any year of the proposed project. Annual continuation awards will depend on the availability of funds, grantee progress in meeting project goals and objectives, timely submission of required data and reports, and compliance with all terms and conditions of award.

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