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Odyssey House Community Health Center (OHCHC), a Federally Qualified Health Center operated by Odyssey House Louisiana (OHL), proposes to partner with local providers and prescribers to develop best practices for prescribing and co-prescribing FDA-approved overdose reversal drugs; train prescribers, providers, first responders and community members in these best practices; and expand access to and utilization of naloxone, substance abuse treatment and behavioral health services for individuals who have experienced an opioid overdose or are at high risk for overdose. Achievement of OHL’s project goals will increase the availability of opioid antagonists and training resources for first responders and bystanders; improve the public’s access to and understanding of naloxone, and the legal protections in place for people who want to obtain it; and prevent opioid overdose deaths by expanding access to appropriate treatment programs. Project activities will take place in the Greater New Orleans region, and the project team will include a Project Director, Licensed Practical Nurse, Licensed Counselor, Medical Assistant, and 3 Rapid Response Outreach Coordinators. With grant funding, OHCHC will develop and publish a best practices and resource guide that takes into account state and local needs; provide ongoing training and education to a wide range of community members; provide naloxone upon discharge to all clients of OHL substance abuse treatment programs and their families; partner with other community substance abuse treatment agencies and FQHCs to ensure naloxone is available for all community members; and establish a “rapid response” team who will directly connect individuals who have experienced an overdose with treatment at OHL. Eligible patients for this program are 1) adult opioid users in the Greater New Orleans area who have experienced an overdose or are at high risk for overdose, particularly those who have a history of substance use disorders and/or co-occurring mental health conditions; 2) family members and peers of opioid users; and 3) any other adult who wishes to obtain naloxone and receive education and training on how to safely administer it to individuals who are at risk of opioid overdose. Project activities will directly reach an estimated 3,000 individuals per year, or 15,000 over five years. OHL is the state’s largest substance abuse treatment provider, and all of OHL’s adult substance abuse treatment clients – including individuals enrolled in OHL’s medically supported detoxification, residential treatment, and/or long-term/intensive outpatient – are connected with OHCHC, where they can receive comprehensive primary and behavioral health care, including access to naloxone and medically assisted treatment.