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The West Virginia Promoting Integration of Primary and Behavioral Health Care Program will serve 20,000 adults with serious mental illness who have co-occurring physical health conditions or chronic diseases and adults with a substance use disorder over the next five years. Using EBPs, three providers will serve residents of 16 counties to improve health and provide mental health services, including SUD treatment. The West Virginia Bureau for Behavioral Health will focus on two target populations outlined in the Promoting Integration of Primary and Behavioral Health Care FOA, adults with serious mental illness who have co-occurring physical health conditions or chronic diseases and adults with a substance use disorder. West Virginians reported the lowest well-being of any state in the U.S. for the past ten years. Health indicators are poor among adult West Virginians, with one in four adults smoking tobacco, 12.9% reporting CVD or stroke, 43.5% report high blood pressure, 72.0% are overweight or obese, and 16.2% diagnosed with diabetes. These factors contribute to the 8.5% of the adult population reporting major depressive episodes, serious mental illness was reported in 5.7%, and 22.9% of adults reported having some type of mental illness. West Virginia has the highest age-adjusted rate of drug overdose deaths involving opioids and the number of HIV cases diagnosed is on the rise. West Virginia has the highest HBV and HCV rates in the nation. Tuberculosis rates are below the national average, but risk factors increase for several vulnerable populations such as the homeless, injection drug users, and those with HIV. Three provider partner agencies were identified to work on this project, Seneca Health Services Inc., Southern Highlands Community Behavioral Health Center, and United Summit Center which cover 16 counties or 1/3 of the state. Annually, an estimated 13,500 unduplicated individuals will be served, with a five-year goal of serving 20,000. Agencies identified ten different EBPs: motivational interviewing, WRAP, WHAM, SBIRT, NEW-R, Million Hearts, CBT, MAT, TIP 45, and collaborative treatment to decrease NAS. There are three main goals and 14 objectives. Goals include promoting the full integration of primary and behavioral health care, improving overall wellness and physical health of adults with a SMI and individuals with SUD, and offer integrated care services related to screening, diagnosis, prevention, and treatment of mental and SUD and co-occurring physical health conditions and chronic disease.