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The Pennsylvania Strategic Prevention Framework for Prescription Drugs (SPF Rx) Project proposes to increase knowledge among adolescents and young adults of the risks of controlled substances, ultimately reducing misuse and associated opioid overdose deaths within identified high need counties. These goals will be achieved by deploying targeted multi-media campaigns to the public, prescribers, and dispensers. Adolescents and young adults aged 15-24 will be a specific population of focus for this project. The Pennsylvania Department of Health (DOH) has identified the following project objectives: 1) Increase awareness and knowledge of the dangers of prescription drug misuse; 2) Increase prescriber and dispenser utilization of the Prescription Drug Monitoring Program (PDMP); 3) Increase utilization of PDMP data in local overdose prevention program planning, implementation, and evaluation. These goals will be achieved by deploying targeted multi-media campaigns to raise awareness of dangers of prescription drug misuse amongst adolescents and young adults (age 15-24); creating strategic messaging and outreach to prescribers and dispensers regarding utilization of the PDMP and application of the Pennsylvania Prescribing Guidelines; and engaging state and local stakeholders relevant to the goals of the project. The Pennsylvania Department of Health, Office of Drug Surveillance and Misuse Prevention (ODSMP), as the lead agency, will utilize the Strategic Prevention Framework model to plan, implement, and evaluate media campaigns and outreach activities. The ODSMP will engage Pennsylvania’s Opioid Command Center to maximize cohesion with existing work underway in the Commonwealth. The Opioid Command Center consists of 16 state agencies, the Office of Attorney General, and the High Intensity Drug Trafficking Area (HIDTA) and is responsible for leading the Commonwealth’s response to the opioid crisis. Additionally, the ODSMP will establish a workgroup consisting of local stakeholders from the identified high need counties to provide guidance on the project.