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SAMHSA is announcing the availability of up to $230 million for the Strategic Prevention Framework Partnerships for Success grant program

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The Substance Abuse and Mental Health Services Administration (SAMHSA) is accepting applications for Strategic Prevention Framework - Partnerships for Success (Short Title: SPF-PFS) grants totaling up to $230 million over 5 years.

The purpose of this program is to address one of the nation’s top substance abuse prevention priorities; underage drinking among persons aged 9 to 20.  At their discretion, states/tribes may also use grant funds to target up to two additional, data-driven substance abuse prevention priorities, such as the use of marijuana, cocaine, or methamphetamine, etc. by individuals ages 9 and above.  The SPF-PFS program is designed to ensure that prevention strategies and messages reach the populations most impacted by substance abuse. The program extends current established cross-agency and community-level partnerships by connecting substance abuse prevention programming to departments of social services and their community service providers. This includes working with populations disproportionately impacted by the consequences of substance use; i.e., children entering the foster care system, transitional youth, and individuals that support persons with substance abuse issues (women, families, parents, caregivers, and young adults).

SAMHSA expects to fund up to 34 grantees from up to $500,000 to $2.26 million per year for up to five years.  The actual award amount may vary, depending on the availability of funds. The funding opportunity announcement for this grant is available at:

WHO CAN APPLY: Eligibility is limited to 1) federally recognized American Indian/Alaska Native (AI/AN) tribes, tribal organizations, Urban Indian Organizations, or consortia of tribes or tribal organizations and 2) states/territories that are not currently receiving funds through SAMHSA’s SPF-PFS grant. SAMHSA is limiting eligibility to these entities because they have the requisite experience and background critical to the success of the SPF-PFS program: 1) an established state/territorial/tribal infrastructure and system in place—rooted in both the Substance Abuse Prevention and Treatment Block Grant and the SPF prevention model—that allows them to quickly build capacity in communities of need, mobilize those communities, and ensure accurate data collection and reporting at the community level; 2) integration of the SPF-based process into their overall state and tribal prevention systems, ensuring a strong, data-driven focus on identifying, selecting, and implementing effective, evidence-based prevention programs, policies, and practices; 3) experience in working collaboratively with communities to achieve substance abuse prevention goals; 4) familiarity and experience with the alignment of behavioral health with primary prevention; and 5) a history of building comprehensive, state- and tribal-level prevention systems over time. Current SPF-PFS and SPF-State Incentive Grant (SPF-SIG) recipients (with the exception of eligible SPF-PFS and SPF-SIG recipients that are in a No Cost Extension) are excluded from applying for the SPF-PFS grant because they already have the resources in place to support the SPF infrastructure and address their areas of highest need. All eligible SPF-PFS recipients that are in a No Cost Extension may still apply for this grant.  See Section II, Table 2 for eligible applicants and their award amounts.

HOW TO APPLY: All applicants must register with the National Institutes of Health’s electronic Research Administration (eRA) Commons in order to submit an application.  This process takes up to six weeks.  If you believe you are interested in applying for this opportunity, you MUST start the registration process immediately.  Do not wait to start this process.  If your organization is not registered and you do not have an active eRA Commons PI account by the deadline, the application will not be accepted. Applicants also must register with the System for Award Management at and

APPLICATION DUE DATE:  July 6, 2018 by 11:59 pm (Eastern Time).  Applications must be received by the due date and time to be considered for review. 

ADDITIONAL INFORMATION:  Applicants with questions about program issues should contact Tonia F. Gray at (240) 276-2492 or In addition, you may also contact Kameisha Bennett at (240) 276-2586 or

For questions on grants management issues contact Eileen Bermudez at (240) 276-1412 or  

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The Substance Abuse and Mental Health Services Administration (SAMHSA) is the agency within the U.S. Department of Health and Human Services (HHS) that leads public health efforts to advance the behavioral health of the nation. SAMHSA’s mission is to lead public health and service delivery efforts that promote mental health, prevent substance misuse, and provide treatments and supports to foster recovery while ensuring equitable access and better outcomes.

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