This CDC document consists of evidence-based strategies to reduce overdose including naloxone distribution and medication-assisted therapy. It aims to assist community leaders, local and regional organizers, non-profit groups, law enforcement, public health, and members of the public in understanding and navigating effective strategies.

This Technical Brief describes promising and innovative medication-assisted treatment (MAT) models of care in primary care settings, describe barriers to MAT implementation, summarize the evidence available on MAT models of care in primary care settings, identifies gaps in the evidence base, and guides future research.

Systematic evidence review and meta-analysis of the efficacy, comparative effectiveness, and harms of medications both FDA approved and others for adults with alcohol-use disorders, and to evaluate the evidence from primary care settings.

Systematic evidence review describing and reviewing the effectiveness of interventions that address disparities among adult patients with serious mental illness.