The objective of this review is to compare the benefits and harms of second-generation antidepressants (SGAs), psychological, complementary and alternative medicine, and exercise treatment options as first-step interventions for adult outpatients with acute-phase major depressive disorder (MDD), and as second-step interventions for patients with MDD who did not achieve remission after a first treatment attempt with SGAs.

Systematic evidence review comparing the effectiveness of strategies to prevent and de-escalate aggressive behaviors in psychiatric patients in acute care settings, including interventions aimed specifically at reducing use of seclusion and restraint.

Systematic evidence review assessing the effectiveness and harms of first- and second-generation antipsychotics FGAs and SGAs used for treating children, adolescents, and young adults.

Systematic evidence review describing and reviewing the effectiveness of interventions that address disparities among adult patients with serious mental illness.

Systematic evidence review examining comparative effectiveness and harms of psychotherapy and medications for childhood anxiety disorders panic disorder, social anxiety disorder, specific phobias, generalized anxiety disorder, and separation anxiety.