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Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder

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The objective of this review is to compare the benefits and harms of second-generation antidepressants (SGAs), psychological, complementary and alternative medicine, and exercise treatment options as first-step interventions for adult outpatients with acute-phase major depressive disorder (MDD), and as second-step interventions for patients with MDD who did not achieve remission after a first treatment attempt with SGAs.
Authoring Agency
Agency for Healthcare Research and Quality (AHRQ)