For Nurse Practitioners: Integrating MOUD into Primary and Other Care Settings
As a nurse practitioner (NP), you play a vital role in the healthcare system, providing essential care to improve your patient’s health and building trusted relationships. This trust positions you to make a significant impact in treating substance use disorders (SUD) in your clinical setting.
According to SAMHSA’s 2024 National Survey on Drug Use and Health, about 1 in 6 Americans ages 12 and older reported having an SUD in the last year. In addition, an estimated 4.8 million people had an opioid use disorder (OUD), and 27.9 people had an alcohol use disorder (AUD).

NPs in primary care, family practices, community health centers, and other non-specialty settings — who often see their patients on a more frequent basis — can play a critical role in diagnosing and treating SUD and providing the support necessary for people to achieve their recovery goals. Chances are, you are already treating patients with other chronic illness in your practice who would benefit from these essential services.
There are various pathways to recovery. The use of Food and Drug Administration (FDA)-approved medications for opioid use disorder (MOUD), including buprenorphine, methadone, and naltrexone, is one component of an evidence-based care plan that also includes counseling, behavioral therapies, and medical and social services to best meet the needs of each individual.
Integrating MOUD into Your Practice
Explore and identify the MOUD protocols and processes that best suit your type of practice. Tailor them to meet the unique needs of your patients and save lives.
With the elimination of the DATA-Waiver (X-Waiver), where state law allows, practitioners (physicians, PAs, and NPs) in a variety of care settings who hold a Drug Enforcement Administration (DEA) registration with Schedule II-V authority can now prescribe buprenorphine for the treatment of OUD without a special waiver and integrate these evidence-based services into their practices.
To effectively integrate MOUD into your practice, it is crucial to understand and address common barriers and misconceptions that may get in the way of treating patients with SUD. The following table summarizes these barriers and provides approaches to overcome them, ensuring that all of your patients receive nonjudgmental responsive care.
The Agency for Health Care Research and Quality (AHRQ), through its Integration Academy, developed the Medications for Opioid Use Disorder Playbook as a practical guide for providing MOUD and immediate care for patients with OUD in primary care and other ambulatory care settings.
This interactive, web-based product has the latest guidance, tools, resources, tips, and examples that address key aspects of MOUD implementation. The Playbook will help you find your own path for implementation by applying knowledge about successful approaches and navigating possible barriers.
Getting Started
All licensed practitioners who hold a Drug Enforcement Administration (DEA) registration with Schedule II–V authority, and where state law allows, can now prescribe buprenorphine.
To prescribe, you must meet one of the following requirements:
Complete eight hours of training on OUD or SUD
Or
- Have graduated in good standing within the past five years from a nurse practitioner school in the United States; this matriculation should include successful completion of an OUD or SUD curriculum.
Visit Training Requirements (MATE Act) Resources for more information about training and how to attest to these requirements when applying for a new or renewed DEA registration.
If you have questions about requirements in your state, contact your state licensing board or local DEA office.
| Barrier/Misconception | Approach | Resource |
|---|---|---|
| Lack of Confidence in Treatment Efficacy | Enhance confidence by learning more about SUD and MOUD. | |
| Need additional knowledge and support | Learn through peer mentoring or by asking questions from other practitioners who are providing services in other care settings. | |
| Insufficient Knowledge and Training | Engage in continuous education and training programs from SAMHSA and PCSS. | |
| Lack of Staff Buy-in | Conduct regular training and discussions to engage all team members and create a supportive environment. | |
| Time Constraints | Streamline workflows, integrate universal screening, and use efficient documentation tools. | |
| Regulatory Barriers | Stay informed about regulatory changes and seek guidance from SAMHSA resources. | |
| Misunderstanding the Nature of SUDs and MOUD | Debunk myths using resources from credible organizations. |
Continuing Education
- For continuing education activities, visit the American Association for Nurse Practitioners (AANP) CE Opportunities webpage.
- One particularly important opportunity is the AANP’s Addressing Substance Use Disorders in Primary Care Bundle. This multi-module series allows learners to select the modules that they want to complete in any order that they want to complete them in. CE/Rx credit and a completion certificate are awarded for each module that is completed.